Paracetomol

This is a time tested analgesic and anti-pyretic. Paracetamol, a para aminophenol derivative, centrally acting analgesic and anti- pyretic. PARACETAMOL:
Cyclooxygenase enzymes COX-3 are in the brain and spinal cord, which is selectively inhibited by
paracetamol, and is distinct from cyclooxygenase enzymes COX-1 and COX-2. It is selective inhibitor of the enzyme COX-3 in the brain and spinal cord explains the effectiveness of Paracetamol in relieving pain and reducing fever without having unwanted gastrointestinal side effects. It has antipyretic as well as analgesic property
► The safest NSAID for long term in Pain
management.
► Complements the efficacy of other NSAIDs.
Dosage: 1 -2 tsf three times daily

Mefenamic Acid
Pharmacokinetic:
Absorption: Usually reaches peak plasma levels 2 to 4 hrs after administration with a half-life of 2 hrs.
Mefenamic acid is a non- steroidal anti- inflammatory drug used to treat pain. Exhibits anti-inflammatory analgesic and Antipyretic. The mechanism of action of Mefenamic acid is similar to other NSAIDs.
Distribution: Mefenamic acid and its metabolites are firmly bound to plasma proteins.
Elimination: Following a single dose , 67% of the total dose is excreted in the urine as unchanged drug or as one of the two metabolites20%-25% of the dose is excreted in the faces during the first three days.
Children: 250 mg three times daily should be taken with food
Composition:
Each 5 ml contains
Mefenamic acid 100 mg
Paracetamol 250 mg
Dosage: 1 -2 tsf three times daily